The identification of addiction-related circuits is critical for explaining addiction processes and developing addiction treatments. And models of functional addiction circuits developed from functional imaging are an effective tool for discovering and verifying addiction circuits. However, analyzing functional imaging data of addiction and detecting functional addiction circuits still have challenges. We have developed a data-driven and end-to-end generative artificial intelligence(AI) framework to address these difficulties. The framework integrates dynamic brain network modeling and novel network architecture networks architecture, including temporal graph Transformer and contrastive learning modules. A complete workflow is formed by our generative AI framework: the functional imaging data, from neurobiological experiments, and computational modeling, to end-to-end neural networks, is transformed into dynamic nicotine addiction-related circuits. It enables the detection of addiction-related brain circuits with dynamic properties and reveals the underlying mechanisms of addiction.

In recent years, multi-scale generative adversarial networks (GANs) have been proposed to build generalized image processing models based on single sample. Constraining on the sample size, multi-scale GANs have much difficulty converging to the global optimum, which ultimately leads to limitations in their capabilities. In this paper, we pioneered the introduction of PAC-Bayes generalized bound theory into the training analysis of specific models under different adversarial training methods, which can obtain a non-vacuous upper bound on the generalization error for the specified multi-scale GAN structure. Based on the drastic changes we found of the generalization error bound under different adversarial attacks and different training states, we proposed an adaptive training method which can greatly improve the image manipulation ability of multi-scale GANs. The final experimental results show that our adaptive training method in this paper has greatly contributed to the improvement of the quality of the images generated by multi-scale GANs on several image manipulation tasks. In particular, for the image super-resolution restoration task, the multi-scale GAN model trained by the proposed method achieves a 100% reduction in natural image quality evaluator (NIQE) and a 60% reduction in root mean squared error (RMSE), which is better than many models trained on large-scale datasets.

深度神经网络（DNNS）的边缘训练是持续学习的理想目标。但是，这受到训练所需的巨大计算能力的阻碍。硬件近似乘数表明，它们在获得DNN推理加速器中获得资源效率的有效性；但是，使用近似乘数的培训在很大程度上尚未开发。为了通过支持DNN培训的近似乘数来构建有效的资源加速器，需要对不同DNN体系结构和不同近似乘数进行彻底评估。本文介绍了近似值，这是一个开源框架，允许使用模拟近似乘数快速评估DNN训练和推理。近似值与TensorFlow（TF）一样用户友好，仅需要对DNN体系结构的高级描述以及近似乘数的C/C ++功能模型。我们通过使用GPU（AMSIM）上的基于基于LUT的近似浮点（FP）乘数模拟器来提高乘数在乘数级别的模拟速度。近似值利用CUDA并有效地将AMSIM集成到张量库中，以克服商业GPU中的本机硬件近似乘数的缺乏。我们使用近似值来评估使用LENET和RESNETS体系结构的小型和大型数据集（包括Imagenet）的近似乘数的DNN训练的收敛性和准确性。与FP32和BFLOAT16乘数相比，评估表明测试准确性相似的收敛行为和可忽略不计的变化。与训练和推理中基于CPU的近似乘数模拟相比，GPU加速近似值快2500倍以上。基于具有本地硬件乘数的高度优化的闭合源Cudnn/Cublas库，原始张量量仅比近似值快8倍。

高信心重叠的预测和准确的对应关系对于以部分到派对方式对齐成对点云至关重要。但是，重叠区域和非重叠区域之间存在固有的不确定性，这些区域一直被忽略并显着影响注册绩效。除了当前的智慧之外，我们提出了一种新颖的不确定性意识到的重叠预测网络，称为Utopic，以解决模棱两可的重叠预测问题。据我们所知，这是第一个明确引入重叠不确定性以指向云注册的人。此外，我们诱导特征提取器通过完成解码器隐式感知形状知识，并为变压器提供几何关系嵌入，以获得转换 - 不变性的几何形状感知特征表示。凭借更可靠的重叠得分和更精确的密度对应关系的优点，即使对于有限的重叠区域的输入，乌托邦也可以实现稳定而准确的注册结果。关于合成和实际基准的广泛定量和定性实验证明了我们的方法优于最先进的方法。代码可从https://github.com/zhileichen99/utopic获得。

相关神经回路的功能改变是在一定时期的药物成瘾中发生的。这些重大变化也通过分析fMRI揭示。然而，由于fMRI的高维度和信噪比差，因此对于图形识别和尼古丁成瘾（NA）和健康控制之间的图形识别和区域级生物标志物检测任务编码有效且健壮的大脑区域嵌入是一项挑战。 HC）组。在这项工作中，我们将大鼠脑的fMRI表示为具有生物学属性的图形，并提出了一种新型特征选择的图形空间注意网络（FGSAN），以提取成瘾的生物标志物并从这些大脑网络中识别。特别是，使用图形空间注意编码器来捕获具有空间信息的时空脑网络的特征。该方法同时采用贝叶斯特征选择策略，以通过约束功能来优化模型并改善分类任务。与成瘾相关的神经成像数据集进行的实验表明，所提出的模型可以获得卓越的性能并检测与成瘾的神经回路相关的可解释的生物标志物。

本文旨在通过介绍第一个中国数学预训练的语言模型〜（PLM）来提高机器的数学智能，以有效理解和表示数学问题。与其他标准NLP任务不同，数学文本很难理解，因为它们在问题陈述中涉及数学术语，符号和公式。通常，它需要复杂的数学逻辑和背景知识来解决数学问题。考虑到数学文本的复杂性质，我们设计了一种新的课程预培训方法，用于改善由基本和高级课程组成的数学PLM的学习。特别是，我们首先根据位置偏见的掩盖策略执行令牌级预训练，然后设计基于逻辑的预训练任务，旨在分别恢复改组的句子和公式。最后，我们介绍了一项更加困难的预训练任务，该任务强制执行PLM以检测和纠正其生成的解决方案中的错误。我们对离线评估（包括九个与数学相关的任务）和在线$ A/B $测试进行了广泛的实验。实验结果证明了与许多竞争基线相比，我们的方法的有效性。我们的代码可在：\ textColor {blue} {\ url {https://github.com/rucaibox/jiuzhang}}}中获得。

风险的准确器官（OAR）分割对于减少治疗后并发症的放射治疗至关重要。达人指南推荐头部和颈部（H＆N）区域的一套超过40桨的桨，然而，由于这项任务的可预测的禁止劳动力成本，大多数机构通过划定较小的桨子和忽视的少数，选择了大量简化的协议与其他桨相关的剂量分布。在这项工作中，我们提出了一种使用深度学习的新颖，自动化和高效的分层OAR分段（SOARS）系统，精确地描绘了一套全面的42 H＆N OAR。 SOARS将42桨分层进入锚，中级和小型和硬质子类别，通过神经结构搜索（NAS）原则，专门为每个类别提供神经网络架构。我们在内在机构中使用176名培训患者建立了SOAR模型，并在六个不同的机构中独立评估了1327名外部患者。对于每个机构评估，它始终如一地表现出其他最先进的方法至少3-5％的骰子得分（在其他度量的相对误差减少36％）。更重要的是，广泛的多用户研究明显证明，98％的SOARE预测只需要非常轻微或没有直接临床验收的修订（节省90％的辐射脑神经工作负载），并且它们的分割和剂量准确度在于或小于帧 - 用户的变化。这些调查结果证实了H＆N癌症放射疗法工作流OAR描绘过程的强烈临床适用性，提高了效率，全面性和质量。

这项工作研究了图像目标导航问题，需要通过真正拥挤的环境引导具有嘈杂传感器和控制的机器人。最近的富有成效的方法依赖于深度加强学习，并学习模拟环境中的导航政策，这些环境比真实环境更简单。直接将这些训练有素的策略转移到真正的环境可能非常具有挑战性甚至危险。我们用由四个解耦模块组成的分层导航方法来解决这个问题。第一模块在机器人导航期间维护障碍物映射。第二个将定期预测实时地图上的长期目标。第三个计划碰撞命令集以导航到长期目标，而最终模块将机器人正确靠近目标图像。四个模块是单独开发的，以适应真实拥挤的情景中的图像目标导航。此外，分层分解对导航目标规划，碰撞避免和导航结束预测的学习进行了解耦，这在导航训练期间减少了搜索空间，并有助于改善以前看不见的真实场景的概括。我们通过移动机器人评估模拟器和现实世界中的方法。结果表明，我们的方法优于多种导航基线，可以在这些方案中成功实现导航任务。

Theoretical properties of bilevel problems are well studied when the lower-level problem is strongly convex. In this work, we focus on bilevel optimization problems without the strong-convexity assumption. In these cases, we first show that the common local optimality measures such as KKT condition or regularization can lead to undesired consequences. Then, we aim to identify the mildest conditions that make bilevel problems tractable. We identify two classes of growth conditions on the lower-level objective that leads to continuity. Under these assumptions, we show that the local optimality of the bilevel problem can be defined via the Goldstein stationarity condition of the hyper-objective. We then propose the Inexact Gradient-Free Method (IGFM) to solve the bilevel problem, using an approximate zeroth order oracle that is of independent interest. Our non-asymptotic analysis demonstrates that the proposed method can find a $(\delta, \varepsilon)$ Goldstein stationary point for bilevel problems with a zeroth order oracle complexity that is polynomial in $d, 1/\delta$ and $1/\varepsilon$.

Brain midline shift (MLS) is one of the most critical factors to be considered for clinical diagnosis and treatment decision-making for intracranial hemorrhage. Existing computational methods on MLS quantification not only require intensive labeling in millimeter-level measurement but also suffer from poor performance due to their dependence on specific landmarks or simplified anatomical assumptions. In this paper, we propose a novel semi-supervised framework to accurately measure the scale of MLS from head CT scans. We formulate the MLS measurement task as a deformation estimation problem and solve it using a few MLS slices with sparse labels. Meanwhile, with the help of diffusion models, we are able to use a great number of unlabeled MLS data and 2793 non-MLS cases for representation learning and regularization. The extracted representation reflects how the image is different from a non-MLS image and regularization serves an important role in the sparse-to-dense refinement of the deformation field. Our experiment on a real clinical brain hemorrhage dataset has achieved state-of-the-art performance and can generate interpretable deformation fields.